You don’t touch Sheldon! Do you want him to explode?
The A.V. Club interview with Jim Parsons is a fantastic read. Parsons plays uber nerd Sheldon on CBS' pleasantly surprising, often very funny Big Bang Theory. His character is the show's Kramer/Barney/Kenneth* breakout, and this is largely due to the deftly comedic performance from Parsons, who never stoops to rudiculing Sheldon's deep-seated social ackwardness. The interview is illuminating; I would love it if more sitcom actors put Parson's level of empathy for Sheldon into their performances, it adds dimension nicely.
* from Seinfeld, How I Met Your Mother, and 30 Rock, respectively.